Post Operative Nausea & Vomiting

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Relevant Article Depot:

PONV

Postoperative nausea and vomiting in pediatric anesthesia

Antiemetic drugs: what to prescribe and when

Effect of Propofol Infusion on Need for Rescue Antiemetics in Postanesthesia Care Unit After Volatile Anesthesia: A Retrospective Cohort Study

The use of propofol as an antiemetic

Is infusion of subhypnotic propofol as effective as dexamethasone in prevention of postoperative nausea and vomiting related to laparoscopic cholecystectomy? A randomized controlled trial

Subhypnotic propofol infusion plus dexamethasone is more effective than dexamethasone alone for the prevention of vomiting in children after tonsillectomy

The cellular mechanisms of the antiemetic action of dexamethasone and related glucocorticoids against vomiting

Fourth Consensus Guidelines for the Management of Postoperative Nausea and Vomiting Erratum

Postoperative Nausea and Vomiting in Pediatric Patients

An update on the management of PONV in a pediatric patient

Test Your Knowledge:Risk factors for PONV

APONVIE From Heron Therapeutics Gains FDA Approval for PONV

WFSA Tutorial 479: Paediatric Postoperative Vomiting

Rescue Treatment of Postoperative Nausea and Vomiting: A Systematic Review of Current Clinical Evidence

Supplemental perioperative intravenous crystalloids for postoperative nausea and vomiting

Aromatherapy for treatment of postoperative nausea and vomiting

Inhaled Isopropyl Alcohol Superior to Oral Ondansetron as an Antiemetic

Stimulation of the wrist acupuncture point PC6 for preventing postoperative nausea and vomiting

The FDA Droperidol Warning: Is It Justified?

Dopamine-Antagonist Antiemetics in PONV Management: Entering a New Era?

Clinical Use of the Pictorial Baxter Retching Faces Scale for the Measurement of Postoperative Nausea in Children

Antiemetic Administration and Its Association with Race: A Retrospective Cohort Study

Factorial Trial of Six Interventions for the Prevention of Postoperative Nausea and Vomiting

Postoperative nausea and vomiting are strongly influenced by postoperative opioid use in a dose-related manner

Prophylaxis for pediatric postoperative nausea and vomiting: a scoping review of clinical trials

Pharmacokinetics and pharmacodynamics of aprepitant for the prevention of postoperative nausea and vomiting in pediatric subjects

Aprepitant and fosaprepitant decrease the effectiveness of hormonal contraceptives

Aprepitant and fosaprepitant drug interactions: a systematic review

Severe acute drug-induced dystonia in the post-operative period requiring tracheal re-intubation

The Effect of Preoperative Gabapentin on Postoperative Nausea and Vomiting: A Meta-Analysis

Perioperative Supplemental Oxygen and Postoperative Nausea and Vomiting: Subanalysis of a Trial, Systematic Review, and Meta-analysis

Effect of Propofol Infusion on Need for Rescue Antiemetics in Postanesthesia Care Unit After Volatile Anesthesia: A Retrospective Cohort Study

The Association of Guideline-Directed Prophylaxis with Postoperative Nausea and Vomiting in Pediatric Patients: A Single-Center, Retrospective Cohort Study

Portnoy Y., M. Glebov, D. Orkin, M. Katsin, H.Berkenstadt. Postoperative Nausea and Vomiting in Pediatrics: Incidence and Guideline Adherence-a Retrospective Cohort Study. Anesth Analg. 2025 Jul 1; 141(1):77–85. DOI: 10.1213/ANE.0000000000007291. Epub 2024 Nov 19. PMID: 39774167.

Benzon H. A., K. Belani, E. C. Cheon. Postoperative Nausea and Vomiting in Children: Challenges and Some Solutions. Anesth Analg. 2025 Jul 1; 141(1):74–76. DOI:10.1213/ANE.0000000000007326. Epub 2025 Feb 14. PMID:39951389.

P6 acupoint injections are as effective as droperidol in controlling early postoperative nausea and vomiting in children

The Safety of Prochlorperazine in Children: A Systematic Review and Meta-Analysis

Ondansetron & Acetaminophen:

The effect of ondansetron on analgesic efficacy of acetaminophen after hysterectomy: A randomized double blinded placebo controlled trial

Acetaminophen and ondansetron: The central serotonergic connection

The influence of ondansetron on the analgesic effect of acetaminophen after laparoscopic hysterectomy

The Effects of Ondansetron on the Analgesic Action of Intravenous Acetaminophen after Tonsillectomy in Children: A Triple-Blind Randomized Controlled Trial

Paracetamol versus Paracetamol Plus Ondansetron on Acute Postoperative Pain

Increased Postoperative Opioid Consumption in the Presence of Coadministration of 5-Hydroxytryptamine Type 3 Antagonists with Acetaminophen: A Hospital Registry Study

Acetaminophen 5-HT3 Antagonist Interaction: Comment

Acetaminophen 5-HT3 Antagonist Interaction: Reply

Gan TJ, Jin Z, Meyer TA. Rescue treatment of postoperative nausea and vomiting: a systematic review of current clinical evidence. Anesth Analg. 2022 Nov; 135(5): 986-1000. PMID: 36048730

Habib AS, Gan TJ. The effectiveness of rescue antiemetics after failure of prophylaxis with ondansetron or droperidol: a preliminary report. J Clin Anesth. 2005 Feb; 17(1): 62-65. PMID: 15721732

Diemunsch P, Conseiller C, Clyti N, Mamet JP. Ondansetron compared with metoclopramide in the treatment of established postoperative nausea and vomiting: the French Ondansetron Study Group. Br J Anaesth. 1997 Sep; 79(3): 322-326. PMID: 9389849

Droperidol’s Effect on QT Interval

Promethazine (Phenergan)

FDA requires updates to labeling for promethazine hydrochloride injection products

WYETH, PETITIONER v. DIANA LEVINE

Starke PR, Weaver J, Chowdhury BA. Boxed warning added to promethazine labeling for pediatric use. N Engl J Med. 2005 Jun; 352(25): 2653. PMID: 15972879