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General
Whole Blood
RBCs
Fresh Frozen Plasma
Cryoprecipitate
Platelets
Iron


[https://pubs.asahq.org/anesthesiology/article/140/1/144/138661/What-s-in-Your-Transfusion-A-Bedside-Guide-to What’s in Your Transfusion? A Bedside Guide to Blood Products and Their Preparation]
[https://pubs.asahq.org/anesthesiology/article/140/1/144/138661/What-s-in-Your-Transfusion-A-Bedside-Guide-to What’s in Your Transfusion? A Bedside Guide to Blood Products and Their Preparation]
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[https://pubmed.ncbi.nlm.nih.gov/?term=RBC+storage+lesion RBC Storage Lesions]
[https://pubmed.ncbi.nlm.nih.gov/?term=RBC+storage+lesion RBC Storage Lesions]


[https://buff.ly/4hbI4O6 Association of Anaesthetists guidelines: the use of blood components and their alternatives 2024]


<b>Massive Transfusion/Hemorrhage Protocol</b>
[https://www.bjanaesthesia.org/article/S0007-0912(24)00561-0/fulltext Perioperative paediatric patient blood management: a narrative review]
 
[https://pubmed.ncbi.nlm.nih.gov/33494884/ Massive Transfusion in Pediatric Patients]


[https://www.jpedsurg.org/article/S0022-3468(21)00676-X/fulltext?rss=yes Massive transfusion in pediatric trauma-does more blood predict mortality?]
[https://www.nature.com/articles/s41577-023-00834-4 The role of platelets in immune-mediated inflammatory disease]


[https://pubmed.ncbi.nlm.nih.gov/34989702/ Plasma and Platelet Transfusion Strategies in Critically Ill Children Following Severe Trauma, Traumatic Brain Injury, and/or Intracranial Hemorrhage: From the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding]
[https://pubmed.ncbi.nlm.nih.gov/29927566/ ANKRD26-Related Thrombocytopenia]


[https://pubmed.ncbi.nlm.nih.gov/30080793/ Pediatric Massive Transfusion: A Systematic Review]
[https://jamanetwork.com/journals/jama/fullarticle/2834703 Platelet Transfusion 2025 AABB and ICTMG International Clinical Practice Guidelines]


[https://pubmed.ncbi.nlm.nih.gov/32547282/ Massive Transfusion Protocols for Pediatric Patients: Current Perspectives]
[https://journals.lww.com/monitor/fulltext/2025/06000/pediatric_patient_blood_management__unique.3.aspx Pediatric Patient Blood Management: Unique Considerations]


[https://blood.gov.au/pbm-module-6 Patient Blood Management Guidelines: Module 6 Neonatal and Paediatrics]
[https://journals.lww.com/monitor/fulltext/2025/08000/perioperative_anticoagulants_and_anesthesia.8.aspx Perioperative Anticoagulants and Anesthesia Consideration: A Comprehensive Review]


[https://onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1111%2Fpan.13574&file=pan13574-sup-0001-Supinfo.pdf Boston Children’s Hospital que Massive Hemorrhage Guidelines]
[https://www.bjanaesthesia.org/article/S0007-0912(24)00561-0/fulltext Perioperative paediatric patient blood management: a narrative review]


[https://pubmed.ncbi.nlm.nih.gov/32351764/ Single-Center Use of Prothrombin Complex Concentrate in Pediatric Patients]
Metcalf RA, Nahirniak S, Guyatt G, Bathla A, White SK, Al-Riyami AZ, Jug RC, La Rocca U, Callum JL, Cohn CS et al: Platelet Transfusion: 2025 AABB and ICTMG International Clinical Practice Guidelines. Jama 2025.


[https://pubmed.ncbi.nlm.nih.gov/35211220/ Prothrombin Complex Concentrates to Treat Coagulation Disturbances: An Overview With a Focus on Use in Infants and Children]
2. Kaufman RM, Djulbegovic B, Gernsheimer T, Kleinman S, Tinmouth AT, Capocelli KE, Cipolle MD, Cohn CS, Fung MK, Grossman BJ et al: Platelet transfusion: a clinical practice guideline from the AABB. Annals of internal medicine 2015, 162(3):205–213.


[https://pubmed.ncbi.nlm.nih.gov/37565019/ Prothrombin Complex Concentrate Utilization in Children's Hospitals]
3. Nahirniak S, Slichter SJ, Tanael S, Rebulla P, Pavenski K, Vassallo R, Fung M, Duquesnoy R, Saw CL, Stanworth S et al: Guidance on platelet transfusion for patients with hypoproliferative thrombocytopenia. Transfus Med Rev 2015, 29(1):3–13.


[https://pubmed.ncbi.nlm.nih.gov/37919775/ Prothrombin complex concentrate (PCC) for treatment of trauma-induced coagulopathy: systematic review and meta-analyses]
4. Chung HH, Morjaria S, Frame J, Riley M, Zhang AW, Martin SC, Bhatia A, Fenelus M, Fallah F, Inumerables F et al: Rethinking the need for a platelet transfusion threshold of 50 × 109/L for lumbar puncture in cancer patients. Transfusion 2020, 60(10):2243–2249.


[https://pubmed.ncbi.nlm.nih.gov/3970376/ Changes in serial platelet counts following massive blood transfusion in pediatric patients]
[https://www.cureus.com/articles/160489-lumbar-puncture-in-thrombocytopenia-the-floor-is-not-firm#!/ Lumbar Puncture in Thrombocytopenia: The Floor Is Not Firm]


[https://pubmed.ncbi.nlm.nih.gov/37917943/ Intravenous Calcium to Decrease Blood Loss During Intrapartum Cesarean Delivery: A Randomized Controlled Trial]
6. Nellis ME, Karam O, Valentine SL, Bateman ST, Remy KE, Lacroix J, Cholette JM, Bembea MM, Russell RT, Steiner ME et al: Executive Summary of Recommendations and Expert Consensus for Plasma and Platelet Transfusion Practice in Critically Ill Children: From the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding (TAXI-CAB). Pediatr Crit Care Med 2022, 23(1):34–51.


Panos NG, Cook AM, John S, Jones GM; Neurocritical Care Society (NCS) Pharmacy Study Group. Factor Xa inhibitor-related intracranial hemorrhage: results from a multicenter, observational cohort receiving prothrombin complex concentrates. Circulation. 2020 May; 141(21): 1681-1689. PMID: 32264698


<b>Reducing blood draw anemia</b>
Connolly SJ, Crowther M, Eikelboom JW, et al. Full study report of andexanet alfa for bleeding associated with factor Xa inhibitors. N Engl J Med. 2019 Apr; 380(14): 1326-1335. PMID: 30730782


[https://link.springer.com/article/10.1007/s12630-023-02643-8 Effect of using smaller blood volume tubes and closed blood collection devices on total blood loss in patients undergoing major cardiac and vascular surgery]
[https://resources.wfsahq.org/wp-content/uploads/UIA-42-Paediatric-Patient-Blood-Management_Article5.pdf WFSA: Paediatric Patient Blood Management: A Forgotten Population?]


[https://link.springer.com/article/10.1007/s12630-023-02548-6 Small-volume tubes to reduce anemia and transfusion (STRATUS): a pilot study]
Goobie SM, Huang Q, Seshadri S, Kordun A, Staffa SJ, Davenport P, et al. [https://pubmed.ncbi.nlm.nih.gov/41218025 Perioperative Blood Transfusion, Postoperative Hemoglobin, and Clinical Outcomes in Neonates: A Retrospective Observational Study From a Large Quaternary Hospital.] Anesthesia and analgesia. 2026;143(2):221–30. Epub 20251111. doi: 10.1213/ane.0000000000007825. PubMed PMID: 41218025.


[https://ccforum.biomedcentral.com/articles/10.1186/s13054-019-2511-9 Interventions to prevent iatrogenic anemia: a Laboratory Medicine Best Practices systematic review]
Stevenson DK, Wong RJ, Chock VY, Pașca AM, Ahern TL. [https://pubmed.ncbi.nlm.nih.gov/42385720 Red Blood Cell Transfusions: Evidence Favors a Restrictive Approach in Neonates. Anesthesia and analgesia.] 2026;143(2):217–9. Epub 20260302. doi: 10.1213/ane.0000000000008002. PubMed PMID: 42385720.


Connolly SJ, Crowther M, Eikelboom JW, et al. Full study report of andexanet alfa for bleeding associated with factor Xa inhibitors. N Engl J Med. 2019 Apr 4; 380(14): 1326-1335. PMID: 30730782
Villeneuve A, Arsenault V, Lacroix J, Tucci M. [https://pubmed.ncbi.nlm.nih.gov/33245826 Neonatal red blood cell transfusion.] Vox Sang. 2021;116(4):366–78. Epub 20201127. doi: 10.1111/vox.13036. PubMed PMID: 33245826.


Siegal DM, Curnutte JT, Connolly SJ, et al. Andexanet alfa for the reversal of factor Xa inhibitor activity. N Engl J Med. 2015 Dec 17; 373(25): 2413-24. PMID: 26559317
Del Vecchio A, Franco C, Petrillo F, D’Amato G. [https://pubmed.ncbi.nlm.nih.gov/27603540 Neonatal Transfusion Practice: When do Neonates Need Red Blood Cells or Platelets?] Am J Perinatol. 2016;33(11):1079–84. Epub 20160907. doi: 10.1055/s-0036-1586106. PubMed PMID: 27603540.


[https://pubmed.ncbi.nlm.nih.gov/30211390/ Measurement of Intraoperative Blood Loss in Pediatric Orthopaedic Patients: Evaluation of a New Method]
Benesch RE, Maeda N, Benesch R. [https://pubmed.ncbi.nlm.nih.gov/5009828 2,3-Diphosphoglycerate and the relative affinity of adult and fetal hemoglobin for oxygen and carbon monoxide.] Biochim Biophys Acta. 1972;257(1):178–82. doi: 10.1016/0005-2795(72)90268-1. PubMed PMID: 5009828.


[https://pubmed.ncbi.nlm.nih.gov/32815042/ Comparison of common perioperative blood loss estimation techniques: a systematic review and meta-analysis]
Lust C, Vesoulis Z, Jackups R, Jr., Liao S, Rao R, Mathur AM. [https://pubmed.ncbi.nlm.nih.gov/30459388 Early red cell transfusion is associated with development of severe retinopathy of prematurity.] Journal of perinatology : official journal of the California Perinatal Association. 2019;39(3):393–400. Epub 20181120. doi: 10.1038/s41372-018-0274-9. PubMed PMID: 30459388; PubMed Central PMCID: PMC6391181.

Latest revision as of 15:07, 17 August 2026

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Relevant Article Depot:


General

Whole Blood

RBCs

Fresh Frozen Plasma

Cryoprecipitate

Platelets

Iron


What’s in Your Transfusion? A Bedside Guide to Blood Products and Their Preparation

Error traps in Pediatric Patient Blood Management in the Perioperative Period

Peri-operative red blood cell transfusion in neonates and infants

Pediatric preoperative blood ordering: when is a type and screen or crossmatch really needed?

Transfusion Strategies for Hemostatic Blood Products in Critically Ill Children: A Narrative Review and Update on Expert Consensus Guidelines

Perioperative Pediatric Erythrocyte Transfusions: Incorporating Hemoglobin Thresholds and Physiologic Parameters in Decision-making

Reference values in healthy children using the Quantra Hemostasis Analyzer, a novel point of care viscoelastic testing device

Pediatric non-red cell blood product transfusion practices: what's the evidence to guide transfusion of the 'yellow' blood products?

How to manage coagulopathies in critically ill patients

Perioperative Considerations in Management of the Severely Bleeding Coagulopathic Patient

Primum, non nocere: Whole blood, prehospital transfusion and anti-D hemolytic disease of the fetus and newborn

Activated 4-Factor Prothrombin Complex Concentrate as a Hemostatic Adjunct for Neonatal Cardiac Surgery: A Propensity Score-Matched Cohort Study

Prehospital tranexamic acid for trauma victims

Pediatric Blood Transfusion Therapy and Patient Blood Management

Evaluation of a Pre-Filled Table and a Flowchart-Based Algorithm as Cognitive Aids to Reduce Deviations in Dose Calculation for Intraoperative Red Blood Cell Transfusions in Children-An International Web-Based Simulation

Clinical and laboratory diagnosis of VWD

Management of VWD

WHO: The urgent need to implement patient blood management: policy brief

What’s in Your Transfusion? A Bedside Guide to Blood Products and Their Preparation

Use of Intravenous Albumin: A Guideline From the International Collaboration for Transfusion Medicine Guidelines

RBC Storage Lesions

Association of Anaesthetists guidelines: the use of blood components and their alternatives 2024

Perioperative paediatric patient blood management: a narrative review

The role of platelets in immune-mediated inflammatory disease

ANKRD26-Related Thrombocytopenia

Platelet Transfusion 2025 AABB and ICTMG International Clinical Practice Guidelines

Pediatric Patient Blood Management: Unique Considerations

Perioperative Anticoagulants and Anesthesia Consideration: A Comprehensive Review

Perioperative paediatric patient blood management: a narrative review

Metcalf RA, Nahirniak S, Guyatt G, Bathla A, White SK, Al-Riyami AZ, Jug RC, La Rocca U, Callum JL, Cohn CS et al: Platelet Transfusion: 2025 AABB and ICTMG International Clinical Practice Guidelines. Jama 2025.

2. Kaufman RM, Djulbegovic B, Gernsheimer T, Kleinman S, Tinmouth AT, Capocelli KE, Cipolle MD, Cohn CS, Fung MK, Grossman BJ et al: Platelet transfusion: a clinical practice guideline from the AABB. Annals of internal medicine 2015, 162(3):205–213.

3. Nahirniak S, Slichter SJ, Tanael S, Rebulla P, Pavenski K, Vassallo R, Fung M, Duquesnoy R, Saw CL, Stanworth S et al: Guidance on platelet transfusion for patients with hypoproliferative thrombocytopenia. Transfus Med Rev 2015, 29(1):3–13.

4. Chung HH, Morjaria S, Frame J, Riley M, Zhang AW, Martin SC, Bhatia A, Fenelus M, Fallah F, Inumerables F et al: Rethinking the need for a platelet transfusion threshold of 50 × 109/L for lumbar puncture in cancer patients. Transfusion 2020, 60(10):2243–2249.

Lumbar Puncture in Thrombocytopenia: The Floor Is Not Firm

6. Nellis ME, Karam O, Valentine SL, Bateman ST, Remy KE, Lacroix J, Cholette JM, Bembea MM, Russell RT, Steiner ME et al: Executive Summary of Recommendations and Expert Consensus for Plasma and Platelet Transfusion Practice in Critically Ill Children: From the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding (TAXI-CAB). Pediatr Crit Care Med 2022, 23(1):34–51.

Panos NG, Cook AM, John S, Jones GM; Neurocritical Care Society (NCS) Pharmacy Study Group. Factor Xa inhibitor-related intracranial hemorrhage: results from a multicenter, observational cohort receiving prothrombin complex concentrates. Circulation. 2020 May; 141(21): 1681-1689. PMID: 32264698

Connolly SJ, Crowther M, Eikelboom JW, et al. Full study report of andexanet alfa for bleeding associated with factor Xa inhibitors. N Engl J Med. 2019 Apr; 380(14): 1326-1335. PMID: 30730782

WFSA: Paediatric Patient Blood Management: A Forgotten Population?

Goobie SM, Huang Q, Seshadri S, Kordun A, Staffa SJ, Davenport P, et al. Perioperative Blood Transfusion, Postoperative Hemoglobin, and Clinical Outcomes in Neonates: A Retrospective Observational Study From a Large Quaternary Hospital. Anesthesia and analgesia. 2026;143(2):221–30. Epub 20251111. doi: 10.1213/ane.0000000000007825. PubMed PMID: 41218025.

Stevenson DK, Wong RJ, Chock VY, Pașca AM, Ahern TL. Red Blood Cell Transfusions: Evidence Favors a Restrictive Approach in Neonates. Anesthesia and analgesia. 2026;143(2):217–9. Epub 20260302. doi: 10.1213/ane.0000000000008002. PubMed PMID: 42385720.

Villeneuve A, Arsenault V, Lacroix J, Tucci M. Neonatal red blood cell transfusion. Vox Sang. 2021;116(4):366–78. Epub 20201127. doi: 10.1111/vox.13036. PubMed PMID: 33245826.

Del Vecchio A, Franco C, Petrillo F, D’Amato G. Neonatal Transfusion Practice: When do Neonates Need Red Blood Cells or Platelets? Am J Perinatol. 2016;33(11):1079–84. Epub 20160907. doi: 10.1055/s-0036-1586106. PubMed PMID: 27603540.

Benesch RE, Maeda N, Benesch R. 2,3-Diphosphoglycerate and the relative affinity of adult and fetal hemoglobin for oxygen and carbon monoxide. Biochim Biophys Acta. 1972;257(1):178–82. doi: 10.1016/0005-2795(72)90268-1. PubMed PMID: 5009828.

Lust C, Vesoulis Z, Jackups R, Jr., Liao S, Rao R, Mathur AM. Early red cell transfusion is associated with development of severe retinopathy of prematurity. Journal of perinatology : official journal of the California Perinatal Association. 2019;39(3):393–400. Epub 20181120. doi: 10.1038/s41372-018-0274-9. PubMed PMID: 30459388; PubMed Central PMCID: PMC6391181.

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