Factors that Modulate Pediatric Pain

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Relevant Article Depot:

The influence of pain, agitation, and their management on the immature brain

Placebo and nocebo effects

Effect of communication on pain during intravenous cannulation: a randomized controlled trial

Nocebo-induced hyperalgesia during local anesthetic injection

The biochemical and neuroendocrine bases of the hyperalgesia nocebo effect

When words are painful: unraveling the mechanisms of the nocebo effect

“This may hurt”: predictors in procedural disclosures may do harm

Guidelines on informed consent in anaesthesia: unrealistic, unethical, untenable

Parental understanding of their child’s risk of anesthesia

Implications of nocebo in anaesthesia care

Efficacy of preemptive analgesia treatments for the management of postoperative pain: a network meta-analysis

Prevalence of chronic pain in children and adolescents with psychiatric conditions

Early repetitive pain in preterm infants in relation to the developing brain

Procedural pain and brain development in premature newborns

Epidemiology and treatment of painful procedures in neonates in intensive care units

Summary proceedings from the neonatal pain-control group

Perioperative Regional Anesthesia on Persistent Opioid Use and Chronic Pain after Noncardiac Surgery: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Comparison of postoperative pain in children after maintenance anaesthesia with propofol or sevoflurane: a systematic review and meta-analysis

Alderman EM, Breuner CC, COMMITTEE ON ADOLESCENCE, et al. Unique Needs of the Adolescent. Pediatrics. 2019;144(6):e20193150. doi:10.1542/peds.2019-3150

Harbaugh CM, Lee JS, Hu HM, et al. Persistent Opioid Use Among Pediatric Patients After Surgery. Pediatrics. 2018;141(1):e20172439. doi:10.1542/peds.2017-2439

O’Brien E, Muhly WT, Kallan MJ, Sutherland TN. High levels of persistent pain among adolescents recovering from anterior cruciate ligament reconstruction: a single-center cohort study. Reg Anesth Pain Med. Published online April 15, 2026:rapm-2025-107537. doi:10.1136/rapm-2025-107537

Helenius L, Yrjälä T, Oksanen H, et al. Pregabalin and Persistent Postoperative Pain Following Posterior Spinal Fusion in Children and Adolescents: A Randomized Clinical Trial. J Bone Joint Surg Am. 2021;103(23):2200-2206. doi:10.2106/JBJS.21.00153

Ellyson AM, Gordon G, Zhou C, Rabbitts JA. Trajectories, Risk Factors, and Impact of Persistent Pain After Major Musculoskeletal Surgery in Adolescents: A Replication Study. J Pain. 2022;23(6):995-1005. doi:10.1016/j.jpain.2021.12.009

Rosenbloom BN, Frederiksen SD, Wang V, et al. Prognostic factors of chronic postsurgical pain in children and adolescents: a systematic review and meta-analysis. Reg Anesth Pain Med. 2025;50(2):144-152. doi:10.1136/rapm-2024-105696

Rosenbloom BN, Pagé MG, Isaac L, et al. Pediatric Chronic Postsurgical Pain And Functional Disability: A Prospective Study Of Risk Factors Up To One Year After Major Surgery. J Pain Res. 2019;12:3079-3098. doi:10.2147/JPR.S210594

Sutherland TN, Hadland SE, Moon J, et al. The Adolescent Surgery Experience (ASE): a survey-based prospective cohort study to measure risk factors for persistent opioid use. BJA Open. 2025;16:100496. doi:10.1016/j.bjao.2025.100496