Ciprofol

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Relevant Article Depot:

Liu C, Wang Z, Zhou J, Li D, Zhang X, Yan M, Liu X, Ren Y, Feng K, Yu M, Sy SKB. Population pharmacokinetic-pharmacodynamic analysis and dose optimisation of ciprofol in paediatric anaesthesia. Br J Anaesth. 2026 Oct;137(4):1088-1097. doi: 10.1016/j.bja.2026.04.077. Epub 2026 Jul 2. PMID: 42392886.

Zhao Q. Clarifying the Assessment of Emergence Agitation and Postoperative Recovery in Young Children Receiving Ciprofol or Propofol for Dental Surgery [Letter]. Drug Des Devel Ther. 2026 Aug 25;20:649468. doi: 10.2147/DDDT.S649468. PMID: 42668828; PMCID: PMC13525765.

Zhang Y, Wu L, Gao Z, Zhang M, Feng C, Zhang H, Zhang H, Liu B. Clarifying the Assessment of Emergence Agitation and Postoperative Recovery in Young Children Receiving Ciprofol or Propofol for Dental Surgery [Response to Letter]. Drug Des Devel Ther. 2026 Sep 12;20:651342. doi: 10.2147/DDDT.S651342. PMID: 42751275; PMCID: PMC13580442.

Pan J, Zhong T, Lv Y, Jiang M, Fang L, Cui X, Wang J, Zeng R. Efficacy and Safety of Ciprofol versus Propofol for Tracheal Intubation in Pediatric Patients Undergoing Laparoscopic Hernia Repair: An Assessor-Blinded Randomised Controlled Trial. Drug Des Devel Ther. 2026 May 22;20:602666. doi: 10.2147/DDDT.S602666. PMID: 42206234; PMCID: PMC13207853.

Yang Q, He W, Li F, Bi S, Jiang Q. Effects of Ciprofol Combined with Varying Doses of Alfentanil on Anesthetic Efficacy and Safety in Pediatric Bronchoscopy: A Randomized Controlled Trial. Drug Des Devel Ther. 2026 Apr 15;20:588144. doi: 10.2147/DDDT.S588144. PMID: 42011227; PMCID: PMC13092255.

Xu W, Xiao H, Shi X, Sun D, Xu H, Zhao C, Ji F. Efficacy and safety of ciprofol for general anesthesia in pediatric strabismus correction surgery: a prospective, randomized, double-blind, non-inferiority study. Front Med (Lausanne). 2026 Mar 10;13:1790750. doi: 10.3389/fmed.2026.1790750. PMID: 41884141; PMCID: PMC13008851.

Wang S, Li Y, Hu Z, Du L, Wang Y, Jiang X, Li L, Shangguan W. Population pharmacokinetics of a single bolus of ciprofol in Chinese pediatric patients. BMC Anesthesiol. 2026 Jan 30;26(1):141. doi: 10.1186/s12871-026-03647-9. PMID: 41612213; PMCID: PMC12930602.

Nie P, Wu D, Du C, Wang X, Zhang H, Xiao H. Determination of the Median Effective Dose (ED50) of Ciprofol for Successful Sedation in Pediatric Patients During General Anesthesia Induction. Drug Des Devel Ther. 2025 Jul 28;19:6391-6397. doi: 10.2147/DDDT.S536118.

Chen Z, Peng T, Zhang S, Yang Q, Qu S, Cao Y, Chen J, Mao Y. Age-Specific Plasma Concentration, Efficacy and Safety of Ciprofol (Cipepofol) for Induction and Maintenance of General Anesthesia in Pediatric Patients Undergoing Elective Surgery: A Single-Arm Prospective, Pragmatic Trial. Clin Drug Investig. 2025 Mar;45(3):137-150. doi: 10.1007/s40261-025-01425-y. Epub 2025 Feb 17. PMID: 39962019.

Wang S, Li Y, Chen F, Liu HC, Pan L, Shangguan W. Comparison of the ED50 of Ciprofol Combined With or Without Fentanyl for Laryngeal Mask Airway Insertion in Children: A Prospective, Randomized, Open-Label, Dose-Response Trial. Drug Des Devel Ther. 2024 Oct 5;18:4471-4480. doi: 10.2147/DDDT.S466603. PMID: 39391355; PMCID: PMC11464411.

Pei D, Zeng L, Xiao T, Wu L, Wang L, Wei S, Du Z, Qu S. The optimal induction dose of ciprofol combined with low-dose rocuronium in children undergoing daytime adenotonsillectomy. Sci Rep. 2023 Dec 14;13(1):22219. doi: 10.1038/s41598-023-49778-8. PMID: 38097763; PMCID: PMC10721598.