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Latest revision as of 02:22, 25 September 2026
All of the following families of cytochrome P450 enzymes increase in activity over the first year of life EXCEPT:
a) CYP1A2
b) CYP2C9 and CYP2C19
c) CYP3A4 and CYP3A7
d) None of the above
Click for Answer
Answer
Answer c.
The CYP3A family, which is responsible for the metabolism of approximately 40% of medications, shows developmental differences in expression.
CYP3A7 is highest at birth and activity decreases over the first year; CYP3A4 levels increase over the first year of life.
Notes
- This question originally printed in the Pediatric Anesthesiology Review Topics kindle book series, and appears courtesy of Naerthwyn Press, LLC.
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