TYK144

All of the following families of cytochrome P450 enzymes increase in activity over the first year of life EXCEPT:

a) CYP1A2

b) CYP2C9 and CYP2C19

c) CYP3A4 and CYP3A7

d) None of the above

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Answer

Answer c.

The CYP3A family, which is responsible for the metabolism of approximately 40% of medications, shows developmental differences in expression.

CYP3A7 is highest at birth and activity decreases over the first year; CYP3A4 levels increase over the first year of life.

This question originally printed in the Pediatric Anesthesiology Review Topics kindle book series, and appears courtesy of Naerthwyn Press, LLC.